The mediator complex subunit Med10 regulates heart valve formation in zebrafish by controlling Tbx2b-mediated Has2 expression and cardiac jelly formation
نویسندگان
چکیده
منابع مشابه
Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish
The extracellular matrix is crucial for organogenesis. It is a complex and dynamic component that regulates cell behavior by modulating the activity, bioavailability and presentation of growth factors to cell surface receptors. Here, we determined the role of the extracellular matrix protein Nephronectin (Npnt) in heart development using the zebrafish model system. The vertebrate heart is forme...
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During gastrulation, optimal adhesion and receptivity to signalling cues are essential for cells to acquire new positions and identities via coordinated cell movements. T-box transcription factors and the Wnt signalling pathways are known to play important roles in these processes. Zebrafish tbx2b, a member of the TBX2 family, has previously been shown to be required for the specification of mi...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2016
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2016.06.088